I keep seeing MOTS-c mentioned in longevity threads but I don’t really get what it is. Is it a hormone, a peptide, something else, and what role does it play in metabolism?
MOTS-c is a small peptide encoded within mitochondrial DNA, which is why it is often called a mitochondrial derived peptide. Researchers have studied it mostly in cells and animals for its possible role in glucose handling, insulin sensitivity, and cellular energy stress responses. The metabolic signals reported so far are interesting but early, and direct human evidence is still very limited. This is general information, not medical advice; longevity peptides have limited human data and are not approved for human use in most countries. Learn more: MOTS-c guide
Makes sense, appreciate the detail.
Healthy skepticism is the right default with longevity compounds.
Thanks, the guide linked above answered the rest.